wt-1 a-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP2478	WT-1 A1	Tyr-Met-Phe-Pro-agn-Ala-Pro-Tyr-Leu
	WT-1 A1 is an attractive target for immunotherapy in patients with pancreatic adenocarcinoma.
T8467	RET V804M-IN-1	RETV804M kinase inhibitor,LUN09945	c-RET
	RET V804M-IN-1 (RETV804M kinase inhibitor) is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).		c-RET
T16098	Islatravir	MK-8591	HIV Protease , Reverse Transcriptase
	Islatravir (MK-8591) is an effective anti-HIV-1 agent. It acts as a nucleoside reverse transcriptase inhibitor (EC50s: 0.068 nM, 3.1 nM, and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively).		HIV Protease , Reverse Transcriptase
T67833	HIV-1 inhibitor-54		HIV Protease
	HIV-1 inhibitor-54 is a potent HIV-1 inhibitor showing anti-HIV activity (EC50 : 32 nM) against WT HIV-1 (strain IIIB) x in MT-4 cells.HIV-1 inhibitor-54 can be used to study viral infections.		HIV Protease
TQ0219	MK-8033		c-Met/HGFR
	MK-8033 is a new and selective dual ATP competitive c-Met/Ron inhibitor (IC50: 1 nM Wt c-Met).		c-Met/HGFR
T9223	RO-0335		Reverse Transcriptase
	RO-0335 is a potent diphenylether nonnucleoside reverse transcriptase inhibitor. RO-0335 inhibits Wt HIV-1 (IC50 = 1.1 nM) and retained activity (IC50< 100 nM) against 92% of a large number of NNRTI-resistant clinical is...		Reverse Transcriptase
T60839	SLMP53-1		p53
	SLMP53-1 is a p53 activator with anti-tumor activity, inhibits wt and mutp53, activates reprogramming of glucose metabolism in xenografted human tumor tissues, and interferes with angiogenesis and migration. SLMP53-1 inh...		p53
T5469	K-Ras-IN-1		Raf , Ras
	K-Ras-IN-1 is a K-Ras inhibitor.		Raf , Ras
T2043	Mutant IDH1-IN-1	IDH1-IN-1	Dehydrogenase , Isocitrate Dehydrogenase (IDH)
	Mutant IDH1-IN-1 is a potent mutant IDH1 R132 h inhibitor with IC50 < 0.1 uM.		Dehydrogenase , Isocitrate Dehydrogenase (IDH)
T10534	BI-4020		EGFR
	BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase. BI-4020 exhibits activity agains the triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines), the d...		EGFR
T4288	HVEGF-IN-1		VEGFR
	hVEGF-IN-1 inhibits human VEGF-A translation and has antitumor activity.		VEGFR
T9428	HM43239		FLT
	HM43239 is an orally active and selective FLT3 inhibitor with IC 50 s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. HM43239 directly inhibits the k...		FLT
T11494	GSK3532795	BMS-955176	Others
	GSK3532795 is a potent, orally active, second-generation HIV-1 maturation inhibitor (EC50s: 10.2, 1.9, 2.7, and 13 nM for HIV-1 WT(human serum), HIV-1 WT, HIV-1 V370A, and HIV-1 ΔV370).		Others
T13061	T338C Src-IN-1		Others
	T338C Src-IN-1 is a potent mutant-Src T338C inhibitor(T338C,IC50=111 nM relative to WT c-Src (10-fold increase)).		Others
T76625	(Lys22)-Amyloid β-Protein (1-42)
	'(Lys22)-Amyloid β-Protein (1-42) represents a mutation of the wild-type (WT) Amyloid β-Protein (1-42) peptide [1].'
T16735	RET-IN-1		Others
	RET-IN-1 is a RET kinase inhibitor (IC50s: 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively).		Others
T12121	MtbHU-IN-1		Others
	MtbHU-IN-1 is a Mycobacterium tuberculosis nucleoid-associated protein HU (MtbHU)inhibitor(binding to WT MtbHU with a Kd of 98 nM).		Others
T75173	WT-TTR inhibitor 1
	Compound 21, a WT-TTR (wild-type Transthyretin) inhibitor, exhibits a 29.05% inhibition rate at a concentration of 100 μM [1].
T63403	WT IDH1 Inhibitor 2
	WT IDH1 Inhibitor 2 is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor (IC50: 120 nM) and is a mutant R132H IDH1 inhibitor, an isoform of GSK321 with wild-type cross-reactivity.
T64103	RET-IN-12
	RET-IN-12 is a RET inhibitor capable of acting on RET(WT) (IC50: 0.3 nM) and RET(V804M) (IC50: 1 nM).